Thanks for the help so far.
I'm on an iMac and have Lr 1.4.1 and Ps CS3. When I finish editing in Ps, I just hit "apple s" to save. Ps then shows that it is writing the tiff file. Then Lr shuts down and I get the error message.
It was not just one image, but 15 or so different images from 2 different shoots.
I will try and look for a corrupt file and delete it.
Strangely, I have not had any problems so far this morning when doing the same thing that was causing Lr to crash repeatedly yesterday.
If it starts happening again I will uninstall and reinstall Lr and browse Adobe's forums for help.
Thanks again...